ORAL PRESENTATIONS

MEETING CONTINUING CHALLENGES IN THE PRACTICE OF FORENSIC TOXICOLOGY Logan B.K. Washington State Toxicology Laboratories, 2203 Airport Way S., Seattle, WA 98134, USA

STABILITY OF DRUGS POSTMORTEM: A REVIEW Drummer O.H. Victorian Institute of Forensic Medicine and Department of Forensic Medicine. Monash University,57-83 Kavanagh Street, Southbank, Melbourne, Victoria, 3006, Australia STABILITY OF TRIHEXYPHENIDYL IN BLOOD AND URINE Battah A.H., Hadidi K.A. Forensic Medicine and Toxicology Division, Faculty of Medicine, University of Jordan, Amman 11942, Jordan. POSTMORTEM INTERPRETATION OF ß2-AGONIST CONCENTRATIONS Couper F.J., Drummer O.H. Victorian Institute of Forensic Medicine and Department of Forensic Medicine. Monash University,57-83 Kavanagh Street, Southbank, Melbourne, Victoria, 3006, Australia BLOOD AND TISSUE DISTRIBUTION OF METHANOL AND FORMIC ACID IN VICTIMS OF MASSIVE INTOXICATION DUE TO INGESTION OF ADULTERATED WINE Ferrari L.A., Nieto R.R., Arado M.G. and Wamba Z. Laboratory of Toxicology and Legal Chemistry, Buenos Aires Court of Justice, La Plata, Argentina DISTRIBUTION OF MORPHINE SPECIES IN POSTMORTEM TISSUES Gerostamoulos J., Drummer O.H. Victorian Institute of Forensic Medicine and Department of Forensic Medicine. Monash University,57-83 Kavanagh Street, Southbank, Melbourne, Victoria, 3006, Australia BLOOD MORPHINE AND MORPHINE-6-GLUCURONIDE IN HEROIN INJECTION FATALITIES Ruprah M. Medical Toxicology Unit, Guy's & St Thomas' Hospital Trust Avonley Road, London, SE 14 5ER SUPERCRITICAL FLUID EXTRACTION AS A SAMPLE PREPARATION TECHNIQUE FOR THE DETERMINATION OF MORPHINE AND 6-MONOACETYL-MORPHINE IN POSTMORTEM BLOOD AND VITREOUS HUMOUR Scott K.S., Oliver J.S. Department of Forensic Medicine and Science, University of Glasgow, Glasgow, G12 8QQ, Scotland, UK DETECTION OF SELECTED DRUGS IN CADAVERIC FEMORAL BONES King C.V., McIntyre I.M., Drummer O.H. Victorian Institute of Forensic Medicine and Department of Forensic Medicine. Monash University,57-83 Kavanagh Street, Southbank 3006, Australia AN ANALYSIS OF LSD IN URINE UNDER VARIOUS STORAGE CONDITIONS McNally A.J., Li Z., Pilcher I., Salamone S.J. Roche Diagnostic Systems, Inc., 1080 US Highway 202, Somerville, NJ 08876, USA ANALYSIS OF NOREPINEPHRINE, EPINEPHRINE, L-DIHYDROXY PHENYLALANINE AND DOPAMINE IN SAMPLES OF POSTMORTEM URINE BY HPLC AND ELECTROCHEMICAL DETECTION Procaccianti P., Argo A. Institute of Legal Medicine, University of Palermo, Via del Vespro 129, 90127 Palermo, Italy

MONITORING DRUG USE Kidwell, D.A.*, Holland, J.C.**, and Blanco, M.A.** *U.S. Naval Research Laboratory, Code 6170, Washington DC, 20375, USA **GeoCenters, Inc., 10903 Indian Head Hwy., Fort Washington, MD 20744, USA URINE DRUG TESTING FOR SOCIAL SERVICE AGENCIES IN NOVA SCOTIA, CANADA Fraser A.D. Toxicology Laboratory, Queen Elizabeth II Health Sciences Centre and Dalhousie University, 1278 Tower Road, Halifax, Nova Scotia, Canada B3H 2Y9 URINE AND SWEAT MONITORING OF ILLICIT COCAINE USE Huestis M.A., Preston K.L., Wong C.J., Silverman K., Cone E.J. National Institute on Drug Abuse, NIH, Addiction Research Center, NIDA, NIH, Baltimore, MD 21224, USA PREVALENCE OF AMPHETAMINE-LIKE DRUGS IN HUMAN URINE Cole K.A.*, Okano C.*, Creghan B.**, Lukey B.**, Bryant P.*, Magluilo J.*, Smith M.L.* *Division Forensic Toxicology, Armed Forces Institute Pathology, Washington, DC, USA **Forensic Toxicology Drug Testing Laboratory, Tripler Army Medical Center, HI, USA CHRONIC MULTIPLE DRUG ABUSE WITH SUICIDAL ENDPOINT Asselborn G., Yegles M., Wennig R. Laboratoire National de Santé, Division Toxicologie, Centre Universitaire de Luxembourg 162A, av. de la Faïencerie, L-1511 LUXEMBOURG SALIVA AS MATRIX FOR CONTROL OF DRUGS AT HOUSE PARTIES Uges D.R.A., Bloemhof H., Molmans B. Laboratory for Clinical and Forensic Toxicology and Drug Analysis, Department of Pharmacy, University Hospital Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands DO THE MORPHINE BLOOD LEVELS OF THE SWISS HEROIN SUBSTITUTION PROGRAM INFLUENCE OUR FORENSIC INTERPRETATIONS? Briellmann T.A. Institute of Forensic Medicine, Dep. of Toxicology and Forensic Chemistry, Pestalozzistrasse 22, 4004 Basel, Switzerland DEVELOPMENT OF DRUGTESTING ON WORKPLACES IN SWEDEN Björklöv P, Dalén P, Ståhle L Division of Clinical Pharmacology, Department of Medical Laboratory Sciences and Technology, Karolinska Institute, Huddinge University Hospital, SE-14186 Huddinge, Sweden BLOOD 11-NOR-D-9-THC-COOH INVESTIGATION IN A FATAL WORKPLACE ACCIDENT Mari F., Bonelli A., Bertol E. Forensic Medicine Institute - Viale Morgagni 85, Florence, Italy THE TOXICOLOGY OF METHADONE AND ITS INVOLVEMENT IN SUDDEN DEATH Drummer O.H. Victorian Institute of Forensic Medicine and Department of Forensic Medicine. Monash University,57-83 Kavanagh Street, Southbank, Melbourne, Victoria, 3006, Australia A VIDEO ABOUT A HPLC METHOD FOR DRUGS OF ABUSE FOR POST GRADUATE EDUCATION Uges D.R.A., Molmans B., Bloemhof H., Bouma P. Laboratory for Clinical and Forensic Toxicology and Drug Analysis, Department of Pharmacy, University Hospital Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands

PSYCHOACTIVE SUBSTANCES, DRUGS AND DRIVING Ferrara S.D.. Centre of Behavioural and Forensic Toxicology, University of Padova, Via Falloppio 50, 35121 Padova, Italy MORPHINE TOXICITY AND THE INTOXICATED DRIVER Hodda A.E.. Division of Analytical Laboratories, Western Sydney Area Health Service, PO box 162 Lidcombe NSW 2141, AUSTRALIA FIRST RESULTS OF THE "BELGIAN TOXICOLOGY AND TRAUMATOLOGY STUDY (BTTS)" Wennig R.*, Verstraete A.** *Laboratoire National de Santé, Division Toxicologie, Centre Universitaire de Luxembourg162A, av. de la Faïencerie, L-1511 LUXEMBOURG **Laboratory of Toxicology, U.Z.Gent, 185, De Pintelaan, B-9000 Gent, BELGIUM FATAL TRAFFIC ACCIDENTS INVOLVING METHAMPHETAMINE Logan B.K. Washington State Toxicology Laboratory, 2203 Airport Way S., Seattle WA 98134 PREVALENCE OF DRUGS OF ABUSE AND MEDICATION IN CONSPICUOUS DRIVERS - AN EPIDEMIOLOGICAL STUDY Möeller M.R., Hartung M. Institute of Legal Medicine, University of Saarland, 66421 Homburg/Saar, Germany DRUG USE AMONG DRIVERS SUSPECTED OF DRIVING UNDER THE INFLUENCE Lillsunde P., Korte T., Seppala T. National Public Health Institute, Mannerheimintie 166 Fin-00300 Helsinki, Finland

ETHNIC DIFFERENCE IN DRUG METABOLISM Yamada M.*, Kozma Z.**, Ikebuchi J.***, Nishimura A.**** and Nishi K.***** *Seibo Jogakuin Women's College, Kyoto, Japan **Medical University School of Pecs, Pecs, Hungary ***Tottori University Faculty of Medicine, Yonago, Japan ****Shiga University of Medical Science, Otsu, Japan WITHIN SUBJECT REPEATED MEASURES OF PHARMACOKINETIC PARAMETERS AFTER MARIJUANA SMOKING Cone E .J. National Institute on Drug Abuse, NIH, Addiction Research Center, Division of Intramural Research, PO Box 5180, Baltimore, MD 21224 USA HEMP TEA VERSUS HEMP MILK: SUBJECTIVE EFFECTS AND ELIMINATION STUDIES OF THC AND ITS MAIN METABOLITES Giroud C., Augsburger M., Rivier L. and Mangin P. Laboratoire de Toxicologie Analytique, IUML, Rue du Bugnon 21, CH-1005, Lausanne, Switzerland INFLUENCE OF CADAVER POSITION ON ETHANOL CONCENTRATIONS IN 13 DIFFERENT RAT TISSUES Repetto M., Jurado C., Garfia A., Hidalgo E., Sanz P., Rodriguez-Vicente C., Garcia-Repetto R., Roca I. Instituto Nacional de Toxicología. P. O. Box 863. 41080, Sevilla. Spain EFFECTS OF CAFFEINE AND SAPONIN ON ALCOHOL ABSORPTION AND METABOLISM Hirose M., Tsukamoto S., Kanegae T., Isobe E., Nagoya T.*, Hojo K.** Department of Legal Medicine, *Department of Common-Use Facilities for Medical Research and **Third Department of Internal Medicine, Nihon University School of Medicine, 30 - 1 Ohyaguchi-Kamimachi, Itabashi-Ku, Tokyo 173, Japan MEASURING URINARY METHANOL AND 5-HYDROXYTRYPTOPHOL AS MARKERS OF RECENT DRINKING AFTER ALCOHOL HAS BEEN CLEARED FROM THE BODY Helander A., Jones A.W.*, Bendtsen, P.* Dept of Clinical Neuroscience, St. Gorans Hospital, Karolinska Institute, Stockholm and *Dept. of Forensic Toxicology and Drug Dependence Unit, University Hospital, Linkoping, Sweden.

ANALYSIS OF OPIATES IN HUMAN HAIR BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Pichini S., Altieri I., Pellegrini M., Pacifici R., Zuccaro P. Clinical Biochemistry Department, National Institute of Health, Rome, Italy A SUSPECTED ACUTE POISONING WITH ACRYLAMIDE. ANALYSIS OF BLOOD AND HAIR FOR ACRYLAMIDE ADDUCTS Dickson S., Heenan M., Cairns E., Sage M., Bergmark E., Kautiainen A. Institute of Environmental Science & Research Limited (ESR), ESR Wellington Science Centre, PO Box 30 547 Lower Hutt, New Zealand APPLICATION OF PUBIC HAIR ANALYSIS FOR LEGAL PURPOSES IN CRETE Tsatsakis A.M. Toxicology Laboratory, Medical School, University of Crete, Stavrakia, Iraklion, 71409 Crete, Greece, PO Box 1393. ENVIRONMENTAL CONTAMINATION CAUSES POSITIVE HAIR ANALYSIS RESULTS Smith F.P., Kidwell D.A.* Department of Justice Sciences, University of Alabama, OB15 UAB, Birmingham, AL 35294, USA *U.S. Naval Research Laboratory, Code 6170, Washington DC, 20375, USA

IMMUNOAFFINITY EXTRACTION OF a- AND ß-AMANITIN FOR THEIR SENSITIVE DETECTION IN BODY FLUIDS BY ATMOSPHERIC PRESSURE IONIZATION ELECTROSPRAY (API-ES) LC-MS Schmitt C.J., Weber A.A., Maurer H.H. Institute of Pharmacology and Toxicology, Department of Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany IN VITRO ADSORPTlON STUDY OF FLUOXETINE ONTO ACTIVATED CHARCOAL AT GASTRIC AND INTESTINAL pH USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUORESCENCE DETECTOR Atta-Politou J.*, Tsitoura A.*, Koupparis M.A.** *Department of Forensic Medicine and Toxicology, School of Medicine, University of Athens, Athens 115 27 **Department of Chemistry, Laboratory of Analytical Chemistry, University of Athens, Panepistimiopolis, Athens 157 71, Greece. TOXICOLOGICAL DETECTION OF ACE INHIBITORS AND THEIR METABOLITES IN URINE BY GC/MS AFTER EXTRACTIVE ALKYLATION Arlt J.W., Maurer H.H. Institute of Pharmacology and Toxicology, Department of Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany DETECTION OF FOUR NEW TRANQUILLIZERS- SEDATIVES DURING THE TOXICOLOGICAL ANALYSIS. Dona A., Athanaselis S., Maravelias C., Koutselinis A. Department of Forensic Medicine and Toxicology, University of Athens, Medical School, 75, M.Asias str., Goudi, Athens, Greece ANALYTICAL FINDINGS IN A SUSPECTED CASE OF TAMPERING WITH A MORPHINE PUMP Bugge A., Morland H., Slordal L. National Institute of Forensic Toxicology, Lovisenberggata 6, 0456 Oslo, Norway FATAL EXPOSURE TO POLYURETHANE GROUT Tytgat J., Bruneel N., Stevens E.*, Daenens P. Laboratory of Toxicology, Laboratory of Clinical Immunology*, University of Leuven, E. Van Evenstraat 4, Kapucijnenvoer 33*, B-3000 Leuven, Belgium "TICTAC" - A CD-ROM FOR THE IDENTIFICATION OF TABLETS & CAPSULES Ramsey J.D. Toxicology Unit, St.George's Hospital Medical School, Cranmer Terrace, London SW17 0RE ANALYSIS OF ILLICIT AMPHETAMINE ANALOGUES BY GAS CHROMATOGRAPHY/FOURIER TRANSFORM INFRARED SPECTROMETRY Dirinck I., Meyer E., Lambert W., De Leenheer A. Laboratorium voor Toxicologie, Universiteit Gent, Harelbekestraat 72. B-9000 Gent, Belgium. IDENTIFICATION AND PROFILES OF IMPURITIES IN ILLICIT METHAMPHETAMINE IN KOREA Yoo Y,C., Chung H.S., Choi H.K., Kim E.M., Kim S.C. National Institute of Scientific Investigation, Division of Narcotics Analysis, 331-1 Shinwol-Dong, Yangchon-Ku, Seoul, Korea

USE OF HIGH SELECTIVITY MS TECHNIQUES TO INCREASE THE RETROSPECTABILITY OF THE USE OF SELECTED DOPING AGENTS Rivier L. Swiss Laboratory for Doping Analysis, Institut of Legal Medicine of the University, Lausanne, Switzerland THE USE OF GC/MS/MS FOR THE DETECTION OF AN UNCOMMON BENZODIAZEPINE IN A URINE SPECIMEN Chan T.W.D., Mok K.K.V. Government Laboratory, Homantin Government Offices, 88 Chung Hau St., Homantin, Kowloon, Hong Kong COUPLED COLUMN LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY (LC/LC/MS/MS): AN EFFECTIVE HYPHENATED TECHNIQUE FOR THE FAST, SELECTIVE AND SENSITIVE BIOANALYSIS OF DRUGS Polettini A., Marrubini Bouland G., Valli A., Montagna M. Department of Legal Medicine and Public Health, University of Pavia, Via Forlanini, 12, 27100 PAVIA DETERMINATION OF MORPHINE, M-6-G, M-3-G, CODEINE, C-6-G AND 6-MAM IN BODY FLUIDS BY MEANS OF LC-APCI-MS Bogusz M.J., Maier R.D., Erkens M., Driessen S. Institute of Forensic Medicine, Aachen University of Technology, D-52057 Aachen, Germany A SENSITIVE ANALYSIS OF THE ACTIVE METABOLITE OF BURGODIN® (DESPROPIONYL-BEZITRAMIDE) IN FORENSIC SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUORESCENCE DETECTION De Baere S., Meyer E., Lambert W., De Leenheer A. Laboratorium voor Toxicologie, Universiteit Gent, Harelbekestraat 72, B-9000 Gent, Belgium A SENSITIVE LIQUID CHROMATOGRAPHY - ELECTROSPRAY - MASS SPECTROMETRY (LC-ES-MS) TECHNIQUE FOR THE DETERMINATION OF LSD AND NOR-LSD IN URINE, AND ITS USE IN THE EVALUATION OF THE BEHRING EMIT II® LSD ASSAY Marquet P.*, Mura P.**, Lacassie E.*, Verneuil B.*, Dupuy J.L.*, Lachatre G.*,*** *Department of Pharmacology and Toxicology, University Hospital, 87042 Limoges Cedex, France **Department of Toxicology, University Hospital, Poitiers, FranceFaculty of Pharmacy, 87025 Limoges Cedex, France ***Laboratory of Toxicology, Faculty of Pharmacy, 87025 Limoges Cedex, France A NON-CANNABINOID IMMUNOGEN USED TO ELICIT ANTIBODIES WITH BROAD CROSS-REACTIVITY TO CANNABINOID METABOLITES Salamone S. J., Hui R., Rosen S. Roche Diagnostic Systems, Inc., 1080 US Highway 202, Somerville, NJ 08876, USA HIGHLY SENSITIVE TIME-RESOLVED FLUOROIMMUNOASSAY OF METHAMPHETAMINE Kimura H.*, Mukaida M.**, Yuan J.***, Wang G.***, Matsumoto K.*** *Department of Forensic Medicine, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, Japan **Department of Forensic Medicine, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama, Japan ***Department of Chemistry, Waseda University, Okubo 3-4-1, Shinjuku-ku, Tokyo, Japan THE SOLID PHASE MICRO-EXTRACTION (SPME) OF AMPHETAMINE AND ITS DERIVATIVES FROM URINE AS A CHOICE OF EXTRACTION TODAY Benko A.*, Dona A.**, Hideg Zs.*, Maravellias C.**, Kerner A.*, Kovacs A.* *National Institute of Forensic Toxicology, Varanno str 2-4, 1146 Budapest, Hungary **Department of Forensic Medicine and Toxicology, University of Athens, Medical School, 75, M.Asias str., Goudi, Athens, Greece CAPILLARY ELECTROPHORESIS, A FIRST CHOICE TECHNIQUE FOR THE CHIRAL ANALYSIS OF ILLICIT DRUGS. APPLICATION TO ANALYSIS OF AMPHETAMINE AND CONGENERS Tagliaro F., Manetto G., Bellini S.*, Pisi P., Scarcella D., Turrina S. and Marigo M. Institute of Forensic Medicine, University of Verona, Verona, Italy, and *Glaxo Wellcome Medicines Research Centre, Verona, Italy COLUMN PACKED IMMOBILIZED b-GLUCURONIDASE AND ARYLSULFATASE FOR THE CLEAVAGE OF CONJUGATES - STABILITY, REUSABILITY AND APPLICATION IN TOXICOLOGICAL ROUTINE ANALYSIS Toennes S.W.H., Maurer H.H. Institute of Pharmacology and Toxicology, Department of Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany ENANTIOSELECTIVE SEPARATION OF METHADONE IN SWEAT BY LC/MS Kintz P., Tracqui A., Ludes B. Institut de Medecine Legale, 11 rue Humann, 67000 STRASBOURG (France) THE ANTILIPEMIC BENFLUOREX LEADS TO POSITIVE AMPHETAMINE FLUORESCENCE POLARIZATION IMMUNOASSAY (FPIA) RESULTS - STUDIES ON THE METABOLISM AND TOXICOLOGICAL DETECTION IN URINE BY GC-MS AND FPIA Kraemer Th., Sick F.D., Maurer H.H. Institute of Pharmacology and Toxicology, Department of Toxicology, University of Saarland, D-66421 Homburg (Saar), Germany