|XXXV TIAFT Annual Meeting||Postmortem Analysis and Drug Stability|
STABILITY OF TRIHEXYPHENIDYL IN BLOOD AND URINE|
Battah A.H., Hadidi K.A.
Forensic Medicine and Toxicology Division, Faculty of Medicine, University of Jordan, Amman 11942, Jordan
Trihexyphenidyl (THP) is an anticholinergic agent with hallucinogenic and euphoric properties, leading to its frequent abuse. In Jordan, the abuse of Trihexyphenidyl (Artane®) has been noted with increasing frequency in recent years amongst jordanian youths. The stability of THP which was added to postmortem blood and urine at concentration of 0.25 mg/ml under different storage temperatures was studied. On day zero and at intervals up to six months, THP was measured by gas chromatography, after solid phase extraction (SFE). During that period there was no significant loss of THP at the storage temperatures -20° and 4° C in the spiked as well as authentic samples. Blood and urine samples stored at 25 °C showed about 14% loss of THP recoveries after the third months of storage, with a P value <0.046. The study demonstrate that the analysis of blood and urine samples containing THP, stored at either -20°, 4° and or 25° C would produce reasonable results and meaningful interpretation.
|Oral Presentations||Abstract 002|