|SOFT - TIAFT 1998||Scientific Session 2||Wednesday October 7, 1998|
|DETECTION TIMES OF MORPHINE AND 6-ACETYLMORPHINE IN URINE AFTER INTRAVENOUS HEROIN|
|Edward J. Cone, Amanda J. Jenkins, William D. Darwin, Michael L. Smith*, Jacqueline Summers*, Eric Shimomura* and Budda D. Paul*|
Addiction Research Center, IRP, NIDA, NIH, Baltimore, MD, USA
Detection times by GC-MS for total morphine and 6-acetylmorphine were determined following intravenous administration of 3, 6 and 12 mg doses of heroin*HCl to 8 male subjects. Subjects provided informed consent and the study was conducted on a closed clinical ward under carefully supervised medical conditions. All urine specimens were collected frozen and analyzed by GC-MS for total morphine and 6-acetyl morphine by DOD protocols. Mean detection times (hours to last positive) ± SEM at different cutoff concentrations are shown in the table.|
The net effect of changing the confirmation cutoff concentration for total morphine, as proposed by DHHS from 300 ng/mL to 2000 ng/mL was to lower detection times to ranges similar to or slightly longer than those obtained for 6-AM. Use of the 4000 ng/mL DOD confirmation cutoff reduced detection times further. Overall, it appears that single doses of heroin will be detected for less than 12 hours at the 2000 ng/mL cutoff concentrations.