|SOFT - TIAFT 1998||Scientific Session 1||Wednesday October 7, 1998|
|DISPOSITION OF HEROIN AND METABOLITES IN MULTIPLE BIOLOGICAL MATRICES AFTER LOW DOSE ORAL HEROIN ADMINISTRATION|
|Amanda J. Jenkins, and Edward J. Cone|
Addiction Research Center, IRP, NIDA, NIH, Baltimore, MD 21224, U.S.A.
|Clinical data regarding the disposition of heroin and metabolites after oral heroin administration is limited to case reports of overdoses by "body packers". We conducted a controlled clinical study during which nine healthy male volunteers with a history of heroin use were administered 10 mg heroin hydrochloride in the form of a gelatin capsule. Blood and saliva specimens were collected prior to drug administration and periodically thereafter up to 24 hours. All urine specimens were collected. Specimens were analyzed by solid phase extraction followed by gas chromatography/mass spectrometry for heroin, 6-acetylmorphine and morphine. The assay had a limit of quantitation (LOQ) of 1 ng/ml for each analyte. The total morphine concentration also was measured in the urine specimens.
These data indicate that after low dose administration of heroin by the oral route, heroin and 6-acetylmorphine are not detected in blood, saliva or urine. However, measurable concentrations of free and total morphine are excreted in the urine for approximately 30 and 53 hours, respectively.