SOFT - TIAFT 1998 Poster Session 1 Wednesday October 7, 1998

John Vasiliades, Leon Glass* and Francis M. Urry**

Toxicology Labs, Inc., Omaha, NB 68114, USA
* Dept. of Veterans Affairs Medical Center, Brecksville, OH 44141, USA
** University of Utah School of Medicine, Salt Lake City, UT, USA

Low dose, fifteen milliliters, of Cold-Pressed Hemp Seed Oil was given to three subjects, two males and one female for 5-7 days. No psychotropic effects were reported. Urine samples were collected on day zero, prior to dosing, and on a daily basis for 10-14 days. Samples were screened for delta-9-tetrahydrocannabinol (THC) metabolites by immunoassay, and confirmed for the major metabolite of THC in urine 11-nor-delta-nine-tetrahydrocannabinol carboxylic acid (9-THCA) by GC/MS. Urine positives occurred 1-2 days after dosing, with the peak occurring at 5-7 days after the first dose. Urine became negative for THC metabolites 5-7 days after the last dose. In two individuals total metabolite concentration did not exceed the 50 ng/mL cutoff. GC/MS confirmation showed concentrations of 9-THCA from 1-11 ng/mL. In one individual urines were positive for THC metabolites in excess of 50 ng/mL on days 1-8 after initial dose. GC/MS confirmation gave concentrations for 9-THCA of 13-30 ng/mL. Low doses of Cold Pressed Hemp Seed Oil may result in positive urines for THC (marijuana) metabolites using the 50 ng/mL screening and 15 ng/mL confirmation cutoff.

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