|SOFT - TIAFT 1998||Poster Session 4||Friday October 9, 1998|
OVER-THE-COUNTER ANABOLIC STEROIDS, 4-ANDROSTEN-3,17-DIONE, 4-ANDROSTEN-3,17-DIOL, AND 19-NOR-4-ANDROSTEN-3,17-DIONE: EXCRETION STUDIES IN MEN|
Victor P. Uralets, Paul A. Gillette
Quest Diagnostics, Inc., 7470 Mission Valley Road, San Diego, CA 92108, USA
|Recently, in November 1997, in addition to the previous appearance of 4-androsten-3,17-dione (1), as a nutritional supplement, two other anabolic steroids, 4-androsten-3,17-diol (2) and 19-nor-4-androsten-3,17-dione (3), became legally available over-the-counter in the United States. Their impact on urinary steroid profiles will be presented for males with different patterns of testosterone to epitestosterone (T/E) ratios.
Steroid 2, being a precursor of testosterone and other androgens, behaves similarly to 1, causing a brief abnormal increase (100 times) of the major urinary steroids: testosterone, epitestosterone, androsterone, etiocholanolone. Steroid 2, like 1, causes temporary increase of T/E for all but low T/E men. 2 undergoes conversion into numerous specific metabolites as well, especially into 3a- and 3b-ol-4-androsten-17-ones and 1.
Steroid 3, converting into nandrolone, appears in urine mainly as 19-norandrosterone and 19-noretiocholanolone, reaching concentrations in the first voids as high as 100,000 ng/mL. After a single oral dose of 50 mg, these remain detectable for at least 7 days and up to 10 days. 19-Nortestosterone and dehydrometabolites are well detectable during the first day of excretion. "Asian" men with low T/E metabolize 3 into the same main products as others do with one exception: 19-norepitestosterone appears in urine as a main intermediate metabolite, whereas for Caucasians 19-nortestosterone is a major.