|Wednesday, August 27||Free Topics|
ANALYSIS OF ILLICIT AMPHETAMINE ANALOGUES BY GAS CHROMATOGRAPHY/FOURIER TRANSFORM INFRARED SPECTROMETRY|
Dirinck I., Meyer E., Lambert W., De Leenheer A.
So called "designer drugs" are popular among recreational drug users for their stimulating and mood-modifying properties. Many of these compounds are derived from the phenethylamine structure. A screening method optimized for amphetamine-like compounds in confiscated powders and tablets with GC/FTIR is presented. Aliquots of the methanolic solutions of the unknown samples are analyzed with PTV-injection on a HP-1 column under the following conditions: initial temperature 60° C held for 0.2 min, 30° C/min ramp to 110° C, held for 1,5 min, 5° C/min ramp to 150° C and 30° C/min ramp to 250° C, held for 10 min. The obtained vapor phase spectra are submitted to a spectral search on a laboratory-made amphetamine library. Recently, two different amphetamine analogues were encountered for the first time in our laboratory. They were identified as 4-bromo-2,5-dimethoxy-phenethylamine (DOBP, Nexus or 2C-B) (1) and N-methyl-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB) (2). Both structures are non-controlled substancesin Belgium. Interestingly, the seizures which were sold as 2C-B, were presented as mini tablets (5 mm in diameter). FT-IR vapor phase spectral data for both compounds are presented and compared with spectral data of related phenethylamines. 2C-B has characteristic absorption bands at 1039, 1210, 1381 and 1491 cm-1, while MBDB shows minor differences from its analogue MDMA at the C-H stretch vibration region. Identity confirmation of the amphetamines was completed with additional GC-MS, HPLC-DAD and NMR data. Quantitative GC/FTIR and /MS analyses were performed on the 2C-B exhibits after derivatization with heptafluorobutyric anhydride. In conclusion, the GC/FTIR method is able to distinguish two new amphetamine analogues from other related designer drugs that are commonly encountered on the Belgian drug scene.
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