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Tuesday, August 26 Metabolism and Disposition of Drugs

Yamada M.*, Kozma Z.**, Ikebuchi J.***, Nishimura A.****, Nishi K.*****
* Seibo Jogakuin Women's College, Kyoto, Japan
** Medical University School of Pecs, Pecs, Hungary
*** Tottori University Faculty of Medicine, Yonago, Japan
**** Shiga University of Medical Science, Otsu, Japan

Polymorphic N-acetyltransferase (NAT2) catalyzes N-acetylation of various arylamine-containing chemicals in the liver and causes N-acetylation polymorphism. Acetylator phenotype in humans has been assessed by various methods with a test drug, such as INH etc., and ethnic variation in N-acetylation capacity has been reported.

We prepared the DNA samples from Japanese, German and some other populations and the NAT2 genotype was determined based on the fact that four alleles in the NAT2 gene differ at single base substitutions which modify restriction enzyme cleavage sites. We compared population distributions of acetylator status deduced from the genotype. The distribution showed differences among populations and slow acetylator, which was found in 9% of Japanese people, was detected in 54% of Germans.

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