|SOFT - TIAFT 1998||Scientific Session 3||Thursday October 8, 1998|
|ORAL CREATINE SUPPLEMENTATION AND ITS EFFECT ON URINARY CREATININE, PH, AND SPECIFIC GRAVITY MEASUREMENTS|
|Jeri D. Ropero-Miller1, Paul L. Doering2, and Bruce A. Goldberger1|
1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine
|Oral creatine supplementation has become a popular performance and strength enhancer among amateur and professional athletes. Creatine is spontaneously converted to creatinine. The objective of this study was to determine the effect of oral creatine supplementation on urinary creatinine, pH, and specific gravity measurements.
Four subjects were administered a loading dose of creatine monohydrate (5 g, 4 times daily for 5 days), followed by maintenance dosing (5 g, 1 time daily for 5 days). All discrete urine specimens were collected during the course of the study that included the collection of urine specimens 2 days prior to and following creatine administration. A total of 307 discrete urine specimens were obtained during the course of the study and the urinary creatinine, pH, and specific gravity values were determined. The data including mean (± SD) are summarized below:
The majority of discrete creatinine and specific gravity values and all discrete pH values were within normal limits. Regression analysis of the discrete specific gravity and creatinine concentration values revealed the following range of correlation coefficient (r2) values: 0.6063 - 0.8274. Individual plots of all discrete urine specimen values (creatinine, specific gravity, pH) versus 'time' did not reveal any apparent effect of creatine administration on these measurements. These data suggest that oral creatine supplementation, given at recommended doses, does not appear to influence the discrete urinary creatinine, specific gravity, or pH values.