|SOFT - TIAFT 1998||Poster Session 4||Friday October 9, 1998|
ACCELERATED SOLVENT EXTRACTION: A NEW TOOL FOR TOXICOLOGICAL SCREENING OF POSTMORTEM SAMPLES?|
Vera A. Coopman, Jan A.Cordonnier and Pascal G. Vandecasteele
Laboratory of Analytical Toxicology, Chemiphar NV, Lieven Bauwensstraat 4, Bruges, Belgium
|Accelerated Solvent Extration (ASE) is a new extraction method that significantly streamlines sample preparation. The solvent is pumped into the extraction cell containing the sample, which is than brought to an elevated temperature and pressure. Minutes later, the extract is transferred from the cell to a standard collection vial for cleanup or analysis. The entire extraction process is fully automated and performed in minutes for fast and easy extraction with low solvent consumption.
Previously, the extraction of biological materials such as liver, kidney an other tissues required large amounts of solvents. Funnel extraction can use from 200 mL to 400 mL of solvent for most tissue samples. Recent and anticipated changes in environmental regulations will cause severe restrictions on the amount of solvent usage in laboratories worldwide. ASE was developed to meet the new requirements for reducing solvent usage in the preparation of tissue samples. The objective of this study was to evaluate wether this technique can be used for toxicological screening of postmortem samples such as liver and urine after disperging them with a solid phase.